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易凡教授受邀为国际SCI学术期刊 Channels撰写关于固有免疫受体与TRP离子通道的文章
作者:  来源:   发布时间:2013-11-13 07:55:14  浏览次数:

Review

New Insights into TRP Channels: Interaction with Pattern Recognition Receptors

 

Huirong Han1,2 and Fan Yi1*

 

Abstract

An increasing number of studies have implicated that the activation of innate immune system and inflammatory mechanisms are of importance in the pathogenesis of numerous diseases. The innate immune system is present in almost all multicellular organisms in response to pathogens or tissue injury, which is carried out via germ-line encoded pattern-recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs) or dangers-associated molecular patterns (DAMPs). Intracellular pathways linking immune and inflammatory response to ion channel expression and function have been recently identified. Among ion channels, transient receptor potential (TRP) channels are a major family of non-selective cation-permeable channels that function as polymodal cellular sensors involved in many physiological and pathological processes. In this review, we summarize current knowledge about classifications, functions and interactions of TRP channels and PRRs, which may provide new insights into their roles in the pathogenesis of inflammatory diseases.

 

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