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陈琳
作者:  来源:  发布时间:2010年06月04日 01:11  浏览次数:

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陈琳(1980.10-),女,医学博士,副教授。2004年毕业于山东大学医学院临床医学专业,获医学学士学位,同年免试推荐为山东大学医学院药理学专业硕博连读研究生。20089月至200910月赴美国East Tennessee State University 联合培养博士研究生学习,2009年获得医学博士学位,留校任教。


科研论文:

(1) Chen L(陈琳)*, Kong L*, Wei X, Wang Y, Wang B, Zhang X, Sun J, Liu H. β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2019 May;23(5):3325-3335. (共同第一,IF=4.252

(2) Cheng L*, Chen L(陈琳)*, Wei X, Wang Y, Ren Z, Zeng S, Zhang X, Wen H, Gao C, Liu H. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease. J Neuroinflammation. 2018 Aug 29;15(1):243.(共同第一,IF=5.763

(3) Chen Lin(陈琳), Ren Zhiping, Wei Xinbing, Wang Shuaishuai, Wang Yimeng, Cheng Yanyan, Gao Hua, Liu Huiqing. Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt. Eur J Pharmacol. 2017 Nov 15;815:98-108. (第一位,IF= 2.73)

(4) Chen Lin(陈琳), Cheng Li, Wei Xinbing, Yuan Zheng, Wu Yanmei, Wang Shuaishuai, Ren Zhiping, Liu Xinyong, Liu Huiqing. Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice. Neurochem Res. 2017 Apr; 42(4):1141-1150. (第一位,IF= 2.453)

(5) Liu Huiqing, Wei Xinbing, Kong Lingjun, Liu Xiaoqian, Cheng Li, Yan Shi, Zhang Xiumei, Chen Lin#(陈琳). NOD2 is involved in the inflammatory response after cerebral ischemia-reperfusion injury and triggers NADPH oxidase 2-derived reactive oxygen species. Int J Biol Sci. 2015 Mar 25;11(5):525-35. (#通讯作者,IF=4.195)

(6) Chen Lin(陈琳), Wei Xinbing, Hou Yunfeng, Liu Xiaoqian, Li Senpeng, Sun Baozhu, Liu Xinyong, Liu Huiqing. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3β pathway in rats. Neurochem Int. 2014 Jan; 66:27-32. (第一位,IF= 2.971)

(7) Chen Lin(陈琳), Xiang Yanxiao, Kong Lingjun, Zhang Xiumei, Sun Baozhu, Wei Xinbing, Liu Huiqing.  Hydroxysafflor Yellow A Protects Against Cerebral Ischemia-Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat. Neurochem Res. 2013; 38(11):2268-75. (第一位,IF= 2.453)

(8) He L*, Li H*, Chen L* (陈琳), Miao J, Jiang Y, Zhang Y, Xiao Z, Hanley G, Li Y, Zhang X, Lesage G, Peng Y, Yin D. Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PLoS One. 2011 Apr 29;6(4):e18190. (*共同第一,IF=4. 244)

(9) Chen L(陈琳) *, Shi W*, Li H*, Sun X, Fan X, Lesage G, Li H, Li Y, Zhang Y, Zhang X, Zhang Y, Yin D.Critical Role of Toll-Like Receptor 9 in Morphine and Mycobacterium tuberculosis-Induced Apoptosis in Mice.  PLoS One. 2010 Feb 19;5(2):e9205.( *共同第一IF=4. 244)

(10)Chen L(陈琳) *, Zhang Y*, Sun X*, Li H, LeSage G, Javer A, Zhang X, Wei X, Jiang Y, Yin D. Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3β pathway. Bioorg Med Chem. 2009 Jul 1;17(13):4378-82. (*共同第一IF=3.151)

主持承担课题:

1    NOD2/β-arrestin1/TRAF6泛素化在缺血性脑损伤中的作用(国家自然基金面上项目818737482019.1-2022.12,56万元)

2    TLR9IDO的调控在缺血性脑损伤中的作用及机制研究(山东省重点研发计划2018GSF1180612018-202015万元)

3    Ang II/NOD2/TRAF6信号网络在缺血性脑损伤中的作用及机制研究(山东省自然科学基金面上项目ZR2017MH0102017.08-2020.0615万元)

4 β-arrestin2TLR9介导的脑缺血再灌注损伤炎症反应中的作用及机制研究(国家自然基金青年基金811008742012.1-2014.12,23万元)陈琳、魏欣冰、王姿颖、张艳、孙玉、谢南昌、相妍笑

5 β-arrestin2TLR9介导的脑缺血再灌注损伤细胞凋亡中的作用及机制(山东省优秀中青年科学家奖励基金2011BSE270782011.10-2014.10,6万元)陈琳、刘慧青、张岫美、魏欣冰、孙玉、相妍笑、刘晓倩

6    TLR9介导的PI3K/Akt/GSK3β通路在脑缺血再灌注损伤细胞凋亡中的作用. (教育部高等学校博士点专项科研基金(新教师类)201001311200532011-20133.6万元)陈琳、张岫美、魏欣冰、安杰、刘慧青、孙玉

7    TLR9介导的PI3K/Akt/GSK3β信号通路在脑缺血再灌注损伤中的作用及机制(中国博士后科学基金201004812602011-2012,3万元)

联系方式:

linchen@sdu.edu.cn   0531-88382605



 
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